UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Endothelin signalling mediates experience-dependent myelination in the CNS

Swire, M; Kotelevtsev, Y; Webb, DJ; Lyons, DA; Ffrench-Constant, C; (2019) Endothelin signalling mediates experience-dependent myelination in the CNS. eLife , 8 , Article e49493. 10.7554/eLife.49493. Green open access

[img]
Preview
Text
Endothelin signalling mediates experience-dependent myelination in the CNS.pdf - Published version

Download (8MB) | Preview

Abstract

Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B and PKC epsilon, regulates the number of myelin sheaths formed by individual oligodendrocytes in mouse and zebrafish. We show that this phenotype is also observed in the prefrontal cortex of mice following social isolation, and is associated with reduced expression of vascular endothelin. Additionally, we show that increasing endothelin signalling rescues this myelination defect caused by social isolation. Together, these results indicate that the vasculature responds to changes in neuronal activity associated with experience by regulating endothelin levels, which in turn affect the myelinating capacity of oligodendrocytes. This pathway may be employed to couple the metabolic support function of myelin to activity-dependent demand and also represents a novel mechanism for adaptive myelination.

Type: Article
Title: Endothelin signalling mediates experience-dependent myelination in the CNS
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.49493
Publisher version: https://doi.org/10.7554/eLife.49493
Language: English
Additional information: © 2019, Swire et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10087385
Downloads since deposit
15Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item