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Experimental assessment of skull aberration and transmission loss at 270 kHz for focused ultrasound stimulation of the primary visual cortex

Albelda Gimeno, L; Martin, E; Wright, O; Treeby, B; (2019) Experimental assessment of skull aberration and transmission loss at 270 kHz for focused ultrasound stimulation of the primary visual cortex. In: Proceedings of the 2019 IEEE International Ultrasonics Symposium (IUS). (pp. pp. 556-559). IEEE: Glasgow, United Kingdom, United Kingdom. Green open access

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Abstract

Transcranial focused ultrasound is a rapidly emerging method for non-invasive neuromodulation and stimulation. However, the skull causes a significant acoustic barrier and can reduce the focal intensity and alter the position and shape of the focus compared to free-field. In this study, the insertion loss and focal distortion due to the skull bone were quantified using three ex vivo human skulls and a focused ultrasound transducer operating at 270 kHz targeted on the approximate positions of the left and right primary visual cortex. Compared to free-field, the average insertion loss was -9.8 dB (± 2.2 dB), while the average focal shift was 1.7 mm (± 0.56 mm) in the lateral direction and 2.8 mm (±4.2 mm) in the axial direction. Overall, the acoustic aberrations were small compared to the size of the focal volume, meaning effective stimulation at this frequency can likely be achieved without patient-specific targeting. However, the insertion loss was significant and should be considered when selecting the target focal intensity for human studies.

Type: Proceedings paper
Title: Experimental assessment of skull aberration and transmission loss at 270 kHz for focused ultrasound stimulation of the primary visual cortex
Event: IEEE International Ultrasonics Symposium 2019
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ULTSYM.2019.8926097
Publisher version: https://doi.org/10.1109/ULTSYM.2019.8926097
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ultrasonic imaging, Acoustics, Transducers, Insertion loss, Skull, Acoustic measurements, Bones
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10087156
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