Twelvetrees, AE;
Lesept, F;
Holzbaur, ELF;
Kittler, JT;
(2019)
The adaptor proteins HAP1a and GRIP1 collaborate to activate kinesin-1 isoform KIF5C.
Journal of Cell Science
, 132
, Article jcs215822. 10.1242/jcs.215822.
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Abstract
Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein-complex in the brain, and co-operate to activate kinesin-1 subunit KIF5C in vitro. Based upon this co-operative activation of kinesin-1, we propose a modification to the kinesin activation model that incorporates stabilisation of the central hinge region known to be critical to autoinhibition of kinesin-1.
| Type: | Article |
|---|---|
| Title: | The adaptor proteins HAP1a and GRIP1 collaborate to activate kinesin-1 isoform KIF5C |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/jcs.215822 |
| Publisher version: | https://doi.org/10.1242/jcs.215822 |
| Language: | English |
| Additional information: | Copyright © 2019. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| Keywords: | Adaptor proteins, Autoinhibition, Kinesin, Microtubule transport, Molecular motor |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10087080 |
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