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DNA methylation aging clocks: challenges and recommendations

Bell, CG; Lowe, R; Adams, PD; Baccarelli, AA; Beck, S; Bell, JT; Christensen, BC; ... Rakyan, VK; + view all (2019) DNA methylation aging clocks: challenges and recommendations. Genome Biology , 20 , Article 249. 10.1186/s13059-019-1824-y. Green open access

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Abstract

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and nonhuman models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual.

Type: Article
Title: DNA methylation aging clocks: challenges and recommendations
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s13059-019-1824-y
Publisher version: https://doi.org/10.1186/s13059-019-1824-y
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/10087072
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