UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Monitoring maturation of neural stem cell grafts within a host microenvironment

Kopach, O; (2019) Monitoring maturation of neural stem cell grafts within a host microenvironment. World Journal of Stem Cells , 11 (11) pp. 982-989. 10.4252/wjsc.v11.i11.982. Green open access

[thumbnail of WJSC-11-982.pdf]
Preview
Text
WJSC-11-982.pdf - Published Version

Download (956kB) | Preview

Abstract

Neural stem cells (NSC) act as a versatile tool for neuronal cell replacement strategies to treat neurodegenerative disorders in which functional neurorestorative mechanisms are limited. While the beneficial effects of such cell-based therapy have already been documented in terms of neurodegeneration of various origins, a neurophysiological basis for improvement in the recovery of neurological function is still not completely understood. This overview briefly describes the cumulative evidence from electrophysiological studies of NSC-derived neurons, aimed at establishing the maturation of differentiated neurons within a host microenvironment, and their integration into the host circuits, with a particular focus on the neurogenesis of NSC grafts within the post-ischemic milieu. Overwhelming evidence demonstrates that the host microenvironment largely regulates the lineage of NSC grafts. This regulatory role, as yet underestimated, raises possibilities for the favoured maturation of a subset of neural phenotypes in order to gain timely remodelling of the impaired brain tissue and amplify the therapeutic effects of NSC-based therapy for recovery of neurological function.

Type: Article
Title: Monitoring maturation of neural stem cell grafts within a host microenvironment
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.4252/wjsc.v11.i11.982
Publisher version: https://doi.org/10.4252/wjsc.v11.i11.982
Language: English
Additional information: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keywords: Neural stem cells, Embryonic progenitors, Neurogenesis, Maturation of neurophysiological properties, Integration into network, Neural stem cell therapy, Neurodegeneration, Ischemic injury
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10087055
Downloads since deposit
43Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item