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Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

Chan, YS; (2020) Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective. Developmental Medicine and Child Neurology , 62 (4) pp. 426-433. 10.1111/dmcn.14437. Green open access

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Abstract

Although the influence of sleep on epilepsy has long been recognized, this relationship has yet to be fully exploited to benefit patients. The past decade has seen significant advances in understanding paediatric sleep, providing a framework by which to properly evaluate the sleep of children with epilepsy, which itself has been subject to increasing scrutiny. The role of sleep in learning and the potential for interictal discharges to disrupt sleep‐related memory consolidation provide a novel perspective for understanding the association of childhood epilepsy with a high rate of intellectual disability. In this review, I outline the evolution of sleep duration, architecture, and homeostasis across childhood, relating this to the development of cognitive functions. I describe how these may be disrupted or preserved in children with epilepsy; in particular, collating data from polysomnography. Finally, I explore how sleep may, in the future, be modulated to improve cognitive outcome in these patients.

Type: Article
Title: Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/dmcn.14437
Publisher version: https://doi.org/10.1111/dmcn.14437
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10087039
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