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Flip the coin: IL-7 and IL-7R in health and disease

Barata, JT; Durum, SK; Seddon, B; (2019) Flip the coin: IL-7 and IL-7R in health and disease. Nature Immunology , 20 pp. 1584-1593. 10.1038/s41590-019-0479-x. Green open access

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Abstract

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their ‘dark side’ as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7–IL-7R signaling axis.

Type: Article
Title: Flip the coin: IL-7 and IL-7R in health and disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41590-019-0479-x
Publisher version: https://doi.org/10.1038/s41590-019-0479-x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10086808
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