Barata, JT;
Durum, SK;
Seddon, B;
(2019)
Flip the coin: IL-7 and IL-7R in health and disease.
Nature Immunology
, 20
pp. 1584-1593.
10.1038/s41590-019-0479-x.
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Abstract
The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their ‘dark side’ as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7–IL-7R signaling axis.
| Type: | Article |
|---|---|
| Title: | Flip the coin: IL-7 and IL-7R in health and disease |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41590-019-0479-x |
| Publisher version: | https://doi.org/10.1038/s41590-019-0479-x |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10086808 |
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