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Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

Hogan, T; Nowicka, M; Cownden, D; Pearson, CF; Yates, AJ; Seddon, B; (2019) Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory. eLife , 8 , Article e48901. 10.7554/eLife.48901. Green open access

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Abstract

Laboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of the forces generating these cells remain unclear. Here, we tracked the generation of memory CD4+ T cell subsets in mice housed in facilities differing in their 'dirtiness'. We found evidence for sequential naive to central memory to effector memory development, and confirmed that both memory subsets are heterogeneous in their rates of turnover. We also inferred that early exposure to self and environmental antigens establishes persistent memory populations at levels determined largely, though not exclusively, by the dirtiness of the environment. After the first few weeks of life, however, these populations are continuously supplemented by new memory cells at rates that are independent of environment.

Type: Article
Title: Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.48901
Publisher version: https://doi.org/10.7554/eLife.48901
Language: English
Additional information: © 2019, Hogan et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: Immunology, inflammation, mouse
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10086756
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