Morris, EC;
Albert, MH;
(2019)
Allogeneic HSCT in Adolescents and Young Adults With Primary Immunodeficiencies.
Frontiers in Pediatrics
, 7
, Article 437. 10.3389/fped.2019.00437.
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Abstract
Significant advances in hematopoietic transplantation over the past 20 years, have facilitated the safe transplantation of older adults with higher co-morbidities. In pediatric practice these advances have simultaneously improved outcomes for sicker children with complex, rare diseases including the primary immunodeficiencies, PID. With more widespread adoption of genetic sequencing, older patients with disease-causing mutations restricted to the hematopoietic system can be identified who may benefit from allogeneic hematopoietic stem cell transplantation (Allo-HSCT). Here we discuss the evidence for Allo-HSCT in adolescent and younger adults (AYAs) with PID.
| Type: | Article |
|---|---|
| Title: | Allogeneic HSCT in Adolescents and Young Adults With Primary Immunodeficiencies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fped.2019.00437 |
| Publisher version: | https://doi.org/10.3389/fped.2019.00437 |
| Language: | English |
| Additional information: | © 2019 Morris and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | primary immunodeficiencies, PID, allogeneic hematopoietic stem cell transplantation, Allo HSCT, adolescents and young adults (AYAs) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10086743 |
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