Pieren, M;
Desfougeres, Y;
Michaillat, L;
Schmidt, A;
Mayer, A;
(2015)
Vacuolar SNARE Protein Transmembrane Domains Serve as Nonspecific Membrane Anchors with Unequal Roles in Lipid Mixing.
The Journal of Biological Chemistry
, 290
(20)
pp. 12821-12832.
10.1074/jbc.M115.647776.
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Abstract
Background: Contribution of SNARE transmembrane domains (TMDs) to membrane fusion is unclear. / Results: Exchange of yeast vacuolar SNARE TMDs against unrelated TMDs yielded normal fusion activities; lipid anchors do not support fusion pore opening. / Conclusion: SNARE TMDs serve as nonspecific membrane anchors in vacuole fusion but they need to be proteinaceous. / Significance: SNARE TMDs participate in fusion pore opening.
| Type: | Article |
|---|---|
| Title: | Vacuolar SNARE Protein Transmembrane Domains Serve as Nonspecific Membrane Anchors with Unequal Roles in Lipid Mixing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1074/jbc.M115.647776 |
| Publisher version: | http://dx.doi.org/10.1074/jbc.M115.647776 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10086660 |
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