Johannsson, G;
Bidlingmaier, M;
Biller, BMK;
Boguszewski, M;
Casanueva, FF;
Chanson, P;
Clayton, PE;
... Jorgensen, JOL; + view all
(2018)
Growth hormone research society perspective on biomarkers of gh action in children and adults.
Endocrine Connections
, 7
(3)
R126-R134.
10.1530/EC-18-0047.
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[20493614 - Endocrine Connections] Growth Hormone Research Society perspective on biomarkers of GH action in children and adults.pdf - Published Version Download (553kB) | Preview |
Abstract
OBJECTIVE: The Growth Hormone Research Society (GRS) convened a Workshop in 2017 to evaluate clinical endpoints, surrogate endpoints and biomarkers during GH treatment of children and adults and in patients with acromegaly. PARTICIPANTS: GRS invited 34 international experts including clinicians, basic scientists, a regulatory scientist and physicians from the pharmaceutical industry. EVIDENCE: Current literature was reviewed and expert opinion was utilized to establish the state of the art and identify current gaps and unmet needs. CONSENSUS PROCESS: Following plenary presentations, breakout groups discussed questions framed by the planning committee. The attendees re-convened after each breakout session to share the group reports. A writing team compiled the breakout session reports into a document that was subsequently discussed and revised by participants. This was edited further and circulated for final review after the meeting. Participants from pharmaceutical companies were not part of the writing process. CONCLUSIONS: The clinical endpoint in paediatric GH treatment is adult height with height velocity as a surrogate endpoint. Increased life expectancy is the ideal but unfeasible clinical endpoint of GH treatment in adult GH-deficient patients (GHDA) and in patients with acromegaly. The pragmatic clinical endpoints in GHDA include normalization of body composition and quality of life, whereas symptom relief and reversal of comorbidities are used in acromegaly. Serum IGF-I is widely used as a biomarker, even though it correlates weakly with clinical endpoints in GH treatment, whereas in acromegaly, normalization of IGF-I may be related to improvement in mortality. There is an unmet need for novel biomarkers that capture the pleiotropic actions of GH in relation to GH treatment and in patients with acromegaly.
| Type: | Article |
|---|---|
| Title: | Growth hormone research society perspective on biomarkers of gh action in children and adults |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1530/EC-18-0047 |
| Publisher version: | https://doi.org/10.1530/EC-18-0047 |
| Language: | English |
| Additional information: | © 2018 Growth Hormone Research Society Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | GH; IGF-I; GH deficiency; acromegaly |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10086576 |
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