Zambon, A;
Giobbe, GG;
Vetralla, M;
Michelino, F;
Urbani, L;
Pantano, MF;
Pugno, NM;
... Spilimbergo, S; + view all
(2019)
Long-term maintenance of dried acellular matrices.
In: Carcel, JA and Clemente, G and GarciaPerez, JV and Mulet, A and Rossello, C, (eds.)
IDS'2018: 21st International Drying Symposium.
(pp. pp. 1091-1097).
Univ Politecnica Valencia: Valencia, Spain.
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Abstract
Dried and sterile acellular esophageal matrix was obtained within a new drying process based on the use of supercritical carbon dioxide (SC-CO2). Experiments were performed coupling a conventional detergent enzymatic treatment with two different drying methods: (i) SC-CO2 drying alone; (ii) dehydration in ethanol and a subsequent SC-CO2 drying. Long term preservation was achieved for several months after drying, demonstrating the maintenance of extracellular matrix (ECM) structure, mechanical properties and biocompatibility within cell repopulation studies in vitro. Overall, the results highlighted the potential of this novel technology to obtain a dry and sterile acellular matrix that can be easily stored for oesophageal regeneration in patients with emergency need.
| Type: | Proceedings paper |
|---|---|
| Title: | Long-term maintenance of dried acellular matrices |
| Event: | 21st International Drying Symposium (IDS) |
| Location: | Valencia, SPAIN |
| Dates: | 11 September 2018 - 14 September 2018 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4995/ids2018.2018.7844 |
| Publisher version: | https://doi.org/10.4995/ids2018.2018.7844 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| Keywords: | decellularized tissue; supercritical drying; carbon dioxide; tissue engineering; long term storage |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10086541 |
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