Gabr, Ayman Khaled Ahmed; (2019) Functional Outcomes of Anterior Cruciate Ligament Reconstruction Surgery. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

Anterior cruciate ligament (ACL) is one of the most common sports injuries with a reported yearly incidence rate of over two million injuries worldwide. The main aim of this thesis is to investigate various aspects related to the functional outcomes of ACLR through a series of clinical studies. Ethical approval was sought and granted by the North of Scotland Research Ethics Service. A systematic review was conducted to investigate the outcome measures used in Level I and II clinical ACLR studies. The review showed wide variability in the outcome measures utilised with no consensus on the ideal outcome instrument or combination of instruments to report the outcome of ACLR. Five-year results from the UK National Ligament Registry (NLR) were analysed with review for limitations of registry data and future recommendations. The data analysed provided a comprehensive review for the demographics, surgical techniques and functional outcomes of ACLR surgery across the UK. NLR data is limited by multiple factors including high rate of incomplete data, duplication of data, poor patient compliance and lack of validation of the data. A study was conducted to examine the hypothesis that patients with ACLR do not return to their pre-injury functional status at two years postoperatively. The study showed significant improvement in patient symptoms postoperatively compare to their post-injury scores, but the majority of patients failed to achieve their pre-injury functional outcome scores at 2 years postoperatively. In a comparative study, the anteromedial portal (AM) technique in femoral tunnel drilling was compared with the trans-tibial (TT) technique with respect to radiological and functional outcomes. The hypothesis was that AM portal produces better functional outcomes compared with TT technique. We found that the AM portal achieved a more anatomical position of the graft but there was no difference between the two techniques in functional outcome at 2 years postoperatively. However, ACLR with the AM portal technique had higher graft failure rate compared with the TT technique. The medium- term outcome of all-inside meniscal repairs was investigated in a longitudinal study. Meniscal repairs with concomitant ACLR had a lower failure rate compared with isolated meniscal repairs. This indicates that surgeons should have a low threshold for repairing meniscal tear during ACLR surgery. The healing response technique was studied in a selected group of patients with complete proximal ACL tears. This technique yielded good functional outcome for most of the patients at 2 years postoperative follow up. The studies included in this thesis provides substantial information for surgeons treating patients with ACL injuries. It provides a platform for further research studies investigating the outcomes of ACLR surgery.

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