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Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias

Antonell, A; Tort-Merino, A; Ríos, J; Balasa, M; Borrego-Écija, S; Auge, JM; Muñoz-García, C; ... Sánchez-Valle, R; + view all (2019) Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias. Alzheimer's & Dementia 10.1016/j.jalz.2019.09.001. (In press).

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Abstract

INTRODUCTION: Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD). METHODS: Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic AD and FTD, and FTD and CJD. We measured cerebrospinal fluid neurofilament light (NF-L), neurogranin (Ng), 14-3-3, and YKL-40 proteins. RESULTS: Biomarkers showed differences in HC subjects versus AD, FTD, and CJD. Disease groups differed between them except AD versus FTD for YKL-40. Only NF-L differed between all stages within the AD continuum. AD and FTD symptomatic mutation carriers presented differences with respect to HC subjects. Applying the AT(N) system, 96% subjects were positive for neurodegeneration if 14-3-3 was used, 94% if NF-L was used, 62% if Ng was used, and 53% if YKL-40 was used. DISCUSSION: Biomarkers of synapse and neurodegeneration differentiate HC subjects from neurodegenerative dementias and between AD, FTD, and CJD. NF-L and 14-3-3 performed similar to total tau when AT(N) system was applied.

Type: Article
Title: Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias
Location: United States
DOI: 10.1016/j.jalz.2019.09.001
Publisher version: https://doi.org/10.1016/j.jalz.2019.09.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 14-3-3, AT(N) system, Alzheimer's disease, Biomarker, Cerebrospinal fluid, Creutzfeldt-Jakob disease, Frontotemporal dementia, MCI due to AD, Mutation carriers, Neurofilament light, Neurogranin, Preclinical AD, YKL-40
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10086218
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