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Motion-corrected reconstruction of parametric images from dynamic PET data with the Synergistic Image Reconstruction Framework (SIRF)

Brown, R; Thomas, BA; Rashidnasab, A; Erlandsson, K; Ovtchinnikov, E; Pasca, E; Reader, A; ... Thielemans, K; + view all (2018) Motion-corrected reconstruction of parametric images from dynamic PET data with the Synergistic Image Reconstruction Framework (SIRF). In: Proceedings of the 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference Proceedings (NSS/MIC). IEEE Green open access

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Abstract

Motion correction has been added to a PET-MR reconstruction tool, SIRF, by incorporating a registration package, NiftyReg. New functionality has been demonstrated in the context of estimating kinetic parameters in the left temporal lobe, comparing direct and indirect reconstructions and evaluating the impact of using motion correction.Principal component analysis was used to detect motion and to determine time frames, while STIR's parametric-OSEM was used to perform the motion-corrected direct parametric reconstruction.It was found that the variance in the left temporal lobe decreased when motion correction was performed, and the same was true of direct reconstructions compared to indirect.With SIRF, the entirety of the demonstrated functionality can be performed from a single Matlab or Python script.

Type: Proceedings paper
Title: Motion-corrected reconstruction of parametric images from dynamic PET data with the Synergistic Image Reconstruction Framework (SIRF)
Event: The 2018 IEEE Nuclear Science Symposium and Medical Imaging
ISBN-13: 978-1-5386-8494-8
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/NSSMIC.2018.8824568
Publisher version: https://doi.org/10.1109/NSSMIC.2018.8824568
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Image reconstruction, Principal component analysis, Temporal lobe, Standards, Dynamics, Tools, Kinetic theory
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10086187
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