UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Emerging quantitative MR imaging biomarkers in inflammatory arthritides

Barendregt, AM; Bray, TJP; Hall-Craggs, MA; Maas, M; (2019) Emerging quantitative MR imaging biomarkers in inflammatory arthritides. European Journal of Radiology , 121 , Article 108707. 10.1016/j.ejrad.2019.108707. Green open access

[thumbnail of Hall-Craggs_Emerging quantitative MR imaging biomarkers in inflammatory arthritides_AAM.pdf]
Preview
Text
Hall-Craggs_Emerging quantitative MR imaging biomarkers in inflammatory arthritides_AAM.pdf - Accepted Version

Download (1MB) | Preview

Abstract

PURPOSE: To review quantitative magnetic resonance imaging (qMRI) methods for imaging inflammation in connective tissues and the skeleton in inflammatory arthritis. This review is designed for a broad audience including radiologists, imaging technologists, rheumatologists and other healthcare professionals. METHODS: We discuss the use of qMRI for imaging skeletal inflammation from both technical and clinical perspectives. We consider how qMRI can be targeted to specific aspects of the pathological process in synovium, cartilage, bone, tendons and entheses. Evidence for the various techniques from studies of both adults and children with inflammatory arthritis is reviewed and critically appraised. RESULTS: qMRI has the potential to objectively identify, characterize and quantify inflammation of the connective tissues and skeleton in both adult and pediatric patients. Measurements of tissue properties derived using qMRI methods can serve as imaging biomarkers, which are potentially more reproducible and informative than conventional MRI methods. Several qMRI methods are nearing transition into clinical practice and may inform diagnosis and treatment decisions, with the potential to improve patient outcomes. CONCLUSIONS: qMRI enables specific assessment of inflammation in synovium, cartilage, bone, tendons and entheses, and can facilitate a more consistent, personalized approach to diagnosis, characterisation and monitoring of disease.

Type: Article
Title: Emerging quantitative MR imaging biomarkers in inflammatory arthritides
Location: Ireland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejrad.2019.108707
Publisher version: https://doi.org/10.1016/j.ejrad.2019.108707
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Arthritis, Cartilage, MRI, Osteitis, Quantification, Synovium
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10086173
Downloads since deposit
286Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item