UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Benefits and Harms of Electrical Neuromodulation for Chronic Pelvic Pain: A Systematic Review

Cottrell, AM; Schneider, MP; Goonewardene, S; Yuan, Y; Baranowski, AP; Engeler, DE; Borovicka, J; ... Williams, ACDC; + view all (2019) Benefits and Harms of Electrical Neuromodulation for Chronic Pelvic Pain: A Systematic Review. [Review]. European Urology Focus 10.1016/j.euf.2019.09.011. (In press).

[img] Text
Williams_benefits & harms neuromod for CPP Cottrell et al 2019.pdf - Accepted version
Access restricted to UCL open access staff until 20 October 2020.

Download (1MB)

Abstract

Context: Patients with chronic pelvic pain (CPP) may have pain refractory to conventional pain management strategies. Neuromodulation could provide relief of pain. Objective: To evaluate the benefits and harms of neuromodulation for CPP. Evidence acquisition: A comprehensive search of EMBASE, PUBMED, and SCOPUS was performed for the entire database to January 2018. Studies were selected, data were extracted, and quality was assessed by two independent reviewers. A meta-analysis was used to combine randomized controlled trials (RCTs); otherwise, a narrative analysis was used. Evidence synthesis: After screening 1311 abstracts, 36 studies including eight RCTs were identified, enrolling 1099 patients. Studies covered a broad range in terms of phenotypes of CPP and methods of neuromodulation. A meta-analysis was possible for percutaneous tibial nerve stimulation and transcutaneous electrical nerve stimulation, which showed improvement in pain. Only narrative synthesis was possible for other modalities (sacral nerve stimulation, spinal cord stimulation, intravaginal electrical stimulation, and pudendal nerve stimulation) which appeared to reduce pain in patients with CPP. Treatments generally improved quality of life but with variable reporting of adverse events. Many studies showed high risks of bias and confounding. Conclusions: While electrical neuromodulation may improve symptoms in CPP, further work is needed with high-quality studies to confirm it. Patient summary: Neuromodulation may be useful in reducing pain and improving quality of life in patients with chronic pelvic pain, but more research is needed.

Type: Article
Title: Benefits and Harms of Electrical Neuromodulation for Chronic Pelvic Pain: A Systematic Review
DOI: 10.1016/j.euf.2019.09.011
Publisher version: https://doi.org/10.1016/j.euf.2019.09.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Chronic pelvic pain, Neuromodulation, Pain relief, Percutaneous tibial nerve stimulation, Transcutaneous electrical nerve stimulation, Sacral nerve stimulation, Spinal cord stimulation, Intravaginal electrical stimulation, Pudendal nerve stimulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
URI: https://discovery.ucl.ac.uk/id/eprint/10086161
Downloads since deposit
2Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item