UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

David, G; Mohammadi, S; Martin, AR; Cohen-Adad, J; Weiskopf, N; Thompson, A; Freund, P; (2019) Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. Nature Reviews Neurology , 15 pp. 718-731. 10.1038/s41582-019-0270-5. Green open access

[img]
Preview
Text (Article)
Thompson David_et_al_NRN_final.pdf - Accepted version

Download (688kB) | Preview
[img]
Preview
Image (Figure 1)
figure01.tiff - Accepted version

Download (382kB) | Preview
[img]
Preview
Image (Figure 2)
figure02.tiff - Accepted version

Download (189kB) | Preview
[img]
Preview
Image (Figure 3)
figure03.tif - Accepted version

Download (641kB) | Preview
[img]
Preview
Image (Figure 4)
Figure04.tiff - Accepted version

Download (331kB) | Preview
[img]
Preview
Image (Supplementary Figure)
Supplementary figure01.tiff - Accepted version

Download (2MB) | Preview

Abstract

Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury — the most common form of which is degenerative cervical myelopathy (DCM) — have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.

Type: Article
Title: Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41582-019-0270-5
Publisher version: https://doi.org/10.1038/s41582-019-0270-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Magnetic resonance imaging, Neurodegeneration, Spinal cord diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10086101
Downloads since deposit
34Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item