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Neurocomputational mechanisms underlying emotional awareness: Insights afforded by deep active inference and their potential clinical relevance

Smith, R; Lane, RD; Parr, T; Friston, KJ; (2019) Neurocomputational mechanisms underlying emotional awareness: Insights afforded by deep active inference and their potential clinical relevance. Neuroscience & Biobehavioral Reviews , 107 pp. 473-491. 10.1016/j.neubiorev.2019.09.002. (In press). Green open access

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Abstract

Emotional awareness (EA) is recognized as clinically relevant to the vulnerability to, and maintenance of, psychiatric disorders. However, the neurocomputational processes that underwrite individual variations remain unclear. In this paper, we describe a deep (active) inference model that reproduces the cognitive-emotional processes and self-report behaviors associated with EA. We then present simulations to illustrate (seven) distinct mechanisms that (either alone or in combination) can produce phenomena – such as somatic misattribution, coarse-grained emotion conceptualization, and constrained reflective capacity – characteristic of low EA. Our simulations suggest that the clinical phenotype of impoverished EA can be reproduced by dissociable computational processes. The possibility that different processes are at work in different individuals suggests that they may benefit from distinct clinical interventions. As active inference makes particular predictions about the underlying neurobiology of such aberrant inference, we also discuss how this type of modelling could be used to design neuroimaging tasks to test predictions and identify which processes operate in different individuals – and provide a principled basis for personalized precision medicine.

Type: Article
Title: Neurocomputational mechanisms underlying emotional awareness: Insights afforded by deep active inference and their potential clinical relevance
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2019.09.002
Publisher version: https://doi.org/10.1016/j.neubiorev.2019.09.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: active inference; emotional awareness; somatic misattribution; emotional working memory; computational neuroscience
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10085949
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