Zheng, SC;
Breeze, CE;
Beck, S;
Dong, D;
Zhu, T;
Ma, L;
Ye, W;
... Teschendorff, AE; + view all
(2019)
EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI.
Bioinformatics
10.1093/bioinformatics/btz833.
(In press).
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Abstract
It is well recognized that cell-type heterogeneity hampers the interpretation of Epigenome-Wide Association Studies (EWAS). Many tools have emerged to address this issue, including several R/Bioconductor packages that infer cell-type composition. Here we present a web application for cell-type deconvolution, which offers the functionality of our EpiDISH Bioconductor/R package in a user-friendly GUI environment. Users can upload their data to infer cell-type composition and differentially methylated cytosines in individual cell-types (DMCTs) for a range of different tissues. Availability and implementation EpiDISH web server is implemented with Shiny in R, and is freely available at https://www.biosino.org/EpiDISH/.
| Type: | Article |
|---|---|
| Title: | EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/bioinformatics/btz833 |
| Publisher version: | https://doi.org/10.1093/bioinformatics/btz833 |
| Language: | English |
| Additional information: | © The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10085921 |
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