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Synthetic Strategies towards the Synthesis of Oxyisocyclointegrin

Smith, RJ; Hawkins, BC; (2019) Synthetic Strategies towards the Synthesis of Oxyisocyclointegrin. European Journal of Organic Chemistry , 2019 (40) pp. 6847-6854. 10.1002/ejoc.201901294. Green open access

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Abstract

Numerous natural products containing oxepine‐fused flavones have been isolated and reported over the last fifty years. This compound class typically possess anti‐proliferative and/or antibacterial properties. Herein we provide a full account of our original synthetic strategies along with further details of our ultimately successful approach to oxyisocyclointegrin.

Type: Article
Title: Synthetic Strategies towards the Synthesis of Oxyisocyclointegrin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ejoc.201901294
Publisher version: https://doi.org/10.1002/ejoc.201901294
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Physical Sciences, Chemistry, Organic, Chemistry, Flavones, Natural products, Oxepines, Oxidative cyclization, Total synthesis, WACKER-TYPE OXIDATION, EFFICIENT SYNTHESIS, ARTOCARPUS-ELASTICUS, CHROMONES, FLAVONES, OLEFINS, FACILE, DEHYDROGENATION, FLAVANONES, DISCOVERY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10085840
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