UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Optical interferometric temperature sensors for intravascular blood flow measurements

Carr, E; Mackle, EC; Finlay, MC; Mosse, CA; Coote, JM; Papakonstantinou, I; Desjardins, AE; (2019) Optical interferometric temperature sensors for intravascular blood flow measurements. In: Amelink, A and Nadkarni, SK, (eds.) Novel Biophotonics Techniques and Applications V. SPIE: Munich, Germany. Green open access

[thumbnail of 1107502.pdf]
Preview
Text
1107502.pdf - Published Version

Download (666kB) | Preview

Abstract

Direct and continuous measurements of blood flow are of significant interest in many medical specialties. In cardiology, intravascular physiological measurements can be of critical importance to determine whether coronary stenting should be performed. Intravascular pressure is a physiological parameter that is frequently measured in clinical practice. An increasing body of evidence suggests that direct measurements of blood flow, as additional physiological parameters, could improve decision making. In this study, we developed a novel fibre optic intravascular flow sensor, which enabled time-of-flight measurements by upstream thermal tagging of blood. This flow sensor comprised a temperature sensitive polymer dome at the distal end of a single mode optical fibre. The dome was continuously interrogated by low coherence interferometry to measure thermally-induced length changes with nanometre-scale resolution. Flow measurements were performed by delivering heat upstream from the sensor with a separate optical fibre, and monitoring the temperature downstream at the dome with a sample rate of 50 Hz. A fabricated flow sensor was characterized and tested within a benchtop phantom, which comprised vessels with lumen diameters that ranged from 2.5 to 5 mm. Water was used as a blood mimicking fluid. For each vessel diameter, a pump provided constant volumetric flow at rates in the range of 5 to 200 ml/min. This range was chosen to represent flow rates encountered in healthy human vessels. Laser light pulses with a wavelength of 1470 nm and durations of 0.4 s were used to perform upstream thermal tagging. These pulses resulted in downstream temperature profiles that varied with the volumetric flow rate.

Type: Proceedings paper
Title: Optical interferometric temperature sensors for intravascular blood flow measurements
Event: European Conferences on Biomedical Optics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2527056
Publisher version: https://doi.org/10.1117/12.2527056
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Flow, pressure, coronary artery disease, low coherence interferometry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10085818
Downloads since deposit
148Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item