UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

Brown, CC; Gudjonson, H; Pritykin, Y; Deep, D; Lavallée, V-P; Mendoza, A; Fromme, R; ... Rudensky, AY; + view all (2019) Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell , 179 (4) 846-863.e24. 10.1016/j.cell.2019.09.035. Green open access

[thumbnail of Brown_Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity_VoR.pdf]
Preview
Text
Brown_Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity_VoR.pdf - Published Version

Download (12MB) | Preview

Abstract

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to initiate T cell responses and direct their differentiation into effector lineages. Classical DCs have been divided into two subsets, cDC1 and cDC2, based on phenotypic markers and their distinct abilities to prime CD8 and CD4 T cells. While the transcriptional regulation of the cDC1 subset has been well characterized, cDC2 development and function remain poorly understood. By combining transcriptional and chromatin analyses with genetic reporter expression, we identified two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORgt, two key transcription factors known to define innate and adaptive lymphocyte subsets. These novel cDC2 lineages were characterized by distinct metabolic and functional programs. Extending our findings to humans revealed conserved DC heterogeneity and the presence of the newly defined cDC2 subsets in human cancer.

Type: Article
Title: Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2019.09.035
Publisher version: https://doi.org/10.1016/j.cell.2019.09.035
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: ATAC-sequencing, T-bet, dendritic cells, myeloid cells, single-cell RNA-sequencing, transcriptional regulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10085726
Downloads since deposit
197Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item