UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Tissue‐resident innate immunity in the lung

Ardain, A; Marakalala, MJ; Leslie, A; (2020) Tissue‐resident innate immunity in the lung. Immunology , 159 (3) pp. 245-256. 10.1111/imm.13143. Green open access

[thumbnail of Marakalala_Tissue-Resident Innate Immunity In The Lung_AAM.pdf]
Preview
Text
Marakalala_Tissue-Resident Innate Immunity In The Lung_AAM.pdf - Accepted Version

Download (16MB) | Preview

Abstract

The lung is a unique organ which must protect against inhaled pathogens and toxins, without mounting a disproportionate response against harmless particulate matter and without compromising its vital function. Tissue-resident immune cells within lung provide local immunity and protection from infection but are also responsible for causing disease when dysregulated. There is a growing appreciation of the importance of tissue-resident memory T-cells to lung immunity, but non-recirculating, tissue-resident, innate immune cells also exist. These cells provide the first line of defence against pulmonary infection and are essential for co-ordinating the subsequent adaptive response. In this review we discuss the main lung-resident innate immune subsets and their functions in common pulmonary diseases, such as influenza, bacterial pneumonia, asthma and inflammatory disorders.

Type: Article
Title: Tissue‐resident innate immunity in the lung
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/imm.13143
Publisher version: https://doi.org/10.1111/imm.13143
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Innate, Lung, Tissue-Resident
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10085669
Downloads since deposit
281Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item