UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

An in silico study of the influence of vessel wall deformation on neointimal hyperplasia progression in peripheral bypass grafts

Donadoni, F; Bonfanti, M; Pichardo-Almarza, C; Homer-Vanniasinkam, S; Dardik, A; Díaz-Zuccarini, V; (2019) An in silico study of the influence of vessel wall deformation on neointimal hyperplasia progression in peripheral bypass grafts. Medical Engineering & Physics , 74 pp. 137-145. 10.1016/j.medengphy.2019.09.011. Green open access

[thumbnail of Manuscript_Repository.pdf]
Preview
Text
Manuscript_Repository.pdf - Accepted Version

Download (1MB) | Preview
[thumbnail of Supplementary material.pdf]
Preview
Text
Supplementary material.pdf - Accepted Version

Download (1MB) | Preview

Abstract

Neointimal hyperplasia (NIH) is a major obstacle to graft patency in the peripheral arteries. A complex interaction of biomechanical factors contribute to NIH development and progression, and although haemodynamic markers such as wall shear stress have been linked to the disease, these have so far been insufficient to fully capture its behaviour. Using a computational model linking computational fluid dynamics (CFD) simulations of blood flow with a biochemical model representing NIH growth mechanisms, we analyse the effect of compliance mismatch, due to the presence of surgical stitches and/or to the change in distensibility between artery and vein graft, on the haemodynamics in the lumen and, subsequently, on NIH progression. The model enabled to simulate NIH at proximal and distal anastomoses of three patient-specific end-to-side saphenous vein grafts under two compliance-mismatch configurations, and a rigid wall case for comparison, obtaining values of stenosis similar to those observed in the computed tomography (CT) scans. The maximum difference in time-averaged wall shear stress between the rigid and compliant models was 3.4 Pa, and differences in estimation of NIH progression were only observed in one patient. The impact of compliance on the haemodynamic-driven development of NIH was small in the patient-specific cases considered.

Type: Article
Title: An in silico study of the influence of vessel wall deformation on neointimal hyperplasia progression in peripheral bypass grafts
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.medengphy.2019.09.011
Publisher version: https://doi.org/10.1016/j.medengphy.2019.09.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Compliance mismatch, Computational fluid dynamics, Moving boundary method, Multi-scale modelling, Neointimal hyperplasia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10085549
Downloads since deposit
138Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item