UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Low-dose Computed Tomography Screening: The (Other) Lung Cancer Revolution

Horst, C; Callister, MEJ; Janes, SM; (2019) Low-dose Computed Tomography Screening: The (Other) Lung Cancer Revolution. Clinical Oncology , 31 (10) pp. 697-701. 10.1016/j.clon.2019.07.022. Green open access

[thumbnail of Horst Clin Onc Editorial Resubmitted 26.7.19.pdf]
Preview
Text
Horst Clin Onc Editorial Resubmitted 26.7.19.pdf - Accepted version

Download (759kB) | Preview

Abstract

The advent of immune checkpoint inhibitors for the treatment of metastatic non-small cell lung cancers has been a bright spot in the otherwise bleak landscape of the UK's deadliest cancer. In a disease where two-thirds of those who present with a new diagnosis will be dead within a year, and survival outcomes have changed little in the last four decades [1], the potential to extend progression-free and overall survival by, on average, 4 months [2] is noteworthy. Immunotherapy may play a starring role in the future of lung cancer treatment but there is a more revolutionary approach to improving lung cancer outcomes: low-dose computed tomography (LDCT) screening. Lung cancer screening (LCS) with LDCT demonstrates considerable lung cancer and all-cause mortality risk reduction [3], [4]. LCS and effective and embedded smoking cessation interventions show synergy, with the mortality reduction of screening essentially doubled by prolonged cessation [5]. However, when it comes to LDCT screening, there is still a hearts-and-minds battle to be won (see Table 1).

Type: Article
Title: Low-dose Computed Tomography Screening: The (Other) Lung Cancer Revolution
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clon.2019.07.022
Publisher version: https://doi.org/10.1016/j.clon.2019.07.022
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10085450
Downloads since deposit
14Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item