UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Population Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates on the First Days of Life

Hallik, M; Ilmoja, M-L; Standing, JF; Soeorg, H; Jalas, T; Raidmäe, M; Uibo, K; ... Metsvaht, T; + view all (2020) Population Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates on the First Days of Life. British Journal of Clinical Pharmacology , 86 (2) pp. 318-328. 10.1111/bcp.14146. Green open access

[thumbnail of Standing_bcp.14146.pdf]
Preview
Text
Standing_bcp.14146.pdf - Published Version

Download (3MB) | Preview

Abstract

Aims: To describe the pharmacokinetics (PK) and concentration‐related effects of dobutamine in critically ill neonates in the first days of life, using nonlinear mixed effects modelling. Methods: Dosing, plasma concentration and haemodynamic monitoring data from a dose‐escalation study were analysed with a simultaneous population PK and pharmacodynamic model. Neonates receiving continuous infusion of dobutamine 5–20 μg kg−1 min−1 were included. Left ventricular ejection fraction (LVEF) and cardiac output of right and left ventricle (RVO, LVO) were measured on echocardiography; heart rate (HR), mean arterial pressure (MAP), peripheral arterial oxygen saturation and cerebral regional oxygen saturation were recorded from patient monitors. Results: Twenty‐eight neonates with median (range) gestational age of 30.4 (22.7–41.0) weeks and birth weight (BW) of 1618 (465–4380) g were included. PK data were adequately described by 1‐compartmental linear structural model. Dobutamine clearance (CL) was described by allometric scaling on BW with sigmoidal maturation function of postmenstrual age (PMA). The final population PK model parameter mean typical value (standard error) estimates, standardised to median BW of 1618 g, were 41.2 (44.5) L h−1 for CL and 5.29 (0.821) L for volume of distribution, which shared a common between subject variability of 29% (17.2%). The relationship between dobutamine concentration and RVO/LVEF was described by linear model, between concentration and LVO/HR/MAP/cerebral fractional tissue oxygen extraction by sigmoidal Emax model. Conclusion: In the postnatal transitional period, PK of dobutamine was described by a 1‐compartmental linear model, CL related to BW and PMA. A concentration–response relationship with haemodynamic variables has been established.

Type: Article
Title: Population Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates on the First Days of Life
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bcp.14146
Publisher version: https://doi.org/10.1111/bcp.14146
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10085133
Downloads since deposit
26Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item