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Local Delivery of Therapeutics to the Inner Ear: The State of the Science

Anderson, CR; Xie, C; Su, MP; Garcia, M; Blackshaw, H; Schilder, AGM; (2019) Local Delivery of Therapeutics to the Inner Ear: The State of the Science. Frontiers in Cellular Neuroscience , 13 , Article 418. 10.3389/fncel.2019.00418. Green open access

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Abstract

BACKGROUND: Advances in the understanding of the genetic and molecular etiologies of inner ear disorders have enabled the identification of therapeutic targets and innovative delivery approaches to the inner ear. As this field grows, the need for knowledge about effective delivery of therapeutics to the inner ear has become a priority. This review maps all clinical and pre-clinical research published in English in the field to date, to guide both researchers and clinicians about local drug delivery methods in the context of novel therapeutics. METHODS: A systematic search was conducted using customized strategies in Cochrane, pubmed and EMBASE databases from inception to 30/09/2018. Two researchers undertook study selection and data extraction independently. RESULTS: Our search returned 12,200 articles, of which 837 articles met the inclusion criteria. 679 were original research and 158 were reviews. There has been a steady increase in the numbers of publications related to inner ear therapeutics delivery over the last three decades, with a sharp rise over the last 2 years. The intra-tympanic route accounts for over 70% of published articles. Less than one third of published research directly assesses delivery efficacy, with most papers using clinical efficacy as a surrogate marker. CONCLUSION: Research into local therapeutic delivery to the inner ear has undergone a recent surge, improving our understanding of how novel therapeutics can be delivered. Direct assessment of delivery efficacy is challenging, especially in humans, and progress in this area is key to understanding how to make decisions about delivery of novel hearing therapeutics.

Type: Article
Title: Local Delivery of Therapeutics to the Inner Ear: The State of the Science
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fncel.2019.00418
Publisher version: https://doi.org/10.3389/fncel.2019.00418
Language: English
Additional information: © 2019 Anderson, Xie, Su, Garcia, Blackshaw and Schilder. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: drug delivery, inner ear, novel therapeutics, systematic review, intratympanic, intracochlear
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10085120
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