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Improving Pulmonary Immunity to Bacterial Pathogens Through Streptococcus pneumoniae Colonisation of the Nasopharynx

Brown, JS; (2019) Improving Pulmonary Immunity to Bacterial Pathogens Through Streptococcus pneumoniae Colonisation of the Nasopharynx. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201910-2047ED. (In press). Green open access

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Abstract

Streptococcus pneumoniae is a common cause of bacterial pneumonia especially in the elderly or those with significant comorbidities, and is also frequently associated with exacerbations of COPD (1, 2). Existing S. pneumoniae vaccines have partial strain coverage, may lack efficacy in high risk groups, and generally seem to have poorer efficacy against pulmonary compared to systemic infection (3,4). Hence alternative strategies to conventional vaccines maybe required to prevent the persisting high morbidity and mortality caused by S. pneumoniae lung infections.

Type: Article
Title: Improving Pulmonary Immunity to Bacterial Pathogens Through Streptococcus pneumoniae Colonisation of the Nasopharynx
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1164/rccm.201910-2047ED
Publisher version: https://doi.org/10.1164/rccm.201910-2047ED
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Colonisation, Human infection model, Streptococcus pneumoniae, alveolar macrophages
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10085103
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