Brown, JS;
(2019)
Improving Pulmonary Immunity to Bacterial Pathogens Through Streptococcus pneumoniae Colonisation of the Nasopharynx.
American Journal of Respiratory and Critical Care Medicine
10.1164/rccm.201910-2047ED.
(In press).
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Abstract
Streptococcus pneumoniae is a common cause of bacterial pneumonia especially in the elderly or those with significant comorbidities, and is also frequently associated with exacerbations of COPD (1, 2). Existing S. pneumoniae vaccines have partial strain coverage, may lack efficacy in high risk groups, and generally seem to have poorer efficacy against pulmonary compared to systemic infection (3,4). Hence alternative strategies to conventional vaccines maybe required to prevent the persisting high morbidity and mortality caused by S. pneumoniae lung infections.
| Type: | Article |
|---|---|
| Title: | Improving Pulmonary Immunity to Bacterial Pathogens Through Streptococcus pneumoniae Colonisation of the Nasopharynx |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1164/rccm.201910-2047ED |
| Publisher version: | https://doi.org/10.1164/rccm.201910-2047ED |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Colonisation, Human infection model, Streptococcus pneumoniae, alveolar macrophages |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10085103 |
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