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Low Myo‐inositol indicating astrocytic damage in a case series of neuromyelitis optica

Ciccarelli, O; Thomas, DL; DeVita, E; Wheeler-Kingshott, CAM; Kachramanoglou, C; Kapoor, R; Leary, S; ... Thompson, AJ; + view all (2013) Low Myo‐inositol indicating astrocytic damage in a case series of neuromyelitis optica. Annals of Neurology , 74 (2) pp. 301-305. 10.1002/ana.23909. Green open access

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Abstract

Astrocytic necrosis is a prominent pathological feature of neuromyelitis optica (NMO) lesions and is clinically relevant. We report 5 NMO‐related cases, all with longitudinally extensive lesions in the upper cervical cord, who underwent cervical cord 1H‐magnetic resonance spectroscopy. Lower myo‐inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level. Therefore, the in vivo quantification of myo‐inositol may distinguish NMO from MS. This is an important step toward developing imaging markers for clinical trials in NMO.

Type: Article
Title: Low Myo‐inositol indicating astrocytic damage in a case series of neuromyelitis optica
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ana.23909
Publisher version: https://doi.org/10.1002/ana.23909
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10084886
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