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Travelling Together: A Unifying Pathomechanism for ALS

Fratta, P; Birsa, N; Tosolini, A; Schiavo, G; (2020) Travelling Together: A Unifying Pathomechanism for ALS. Trends in Neurosciences , 43 (1) pp. 1-2. 10.1016/j.tins.2019.10.006. Green open access

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Abstract

Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting that RNA granules ‘hitchhike’ on LAMP1-positive organelles using annexin A11 as a tether.

Type: Article
Title: Travelling Together: A Unifying Pathomechanism for ALS
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2019.10.006
Publisher version: https://doi.org/10.1016/j.tins.2019.10.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: amyotrophic lateral sclerosis, annexin A11, axonal transport, LAMP1-positive organelles, RNA granules
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10084838
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