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Relapse in Anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis

Salama, AD; (2019) Relapse in Anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis. Kidney International Reports 10.1016/j.ekir.2019.10.005. (In press). Green open access

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Abstract

Clinical relapses are common in ANCA associated vasculitis, necessitating repeated treatment with immunosuppressive therapy, and increasing the risks of severe adverse events. Better understanding the basis of relapse would help stratify patients, testing the notion that more treatment may prevent development of relapse, while in those at low risk of disease flares, treatment minimisation may be appropriate, reducing risks of adverse events, most notably infectious complications and drug toxicity. However, relapse can only occur following remission, and although defining clinical remission may seem straightforward, there is evidence in many remission patients of persistent inflammatory and immunological activity, at levels above those found in healthy individuals. This suggests that we may not truly be achieving disease remission in many patients and these persistent responses may set the patient up for subsequent disease flares. Understanding the underlying pathophysiological basis of disease activity and remission is paramount to help define better biomarkers of relapse, which should positively impact on adverse events and patient outcomes.

Type: Article
Title: Relapse in Anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ekir.2019.10.005
Publisher version: https://doi.org/10.1016/j.ekir.2019.10.005
Language: English
Additional information: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10084649
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