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Pathways from childhood maltreatment to cardiometabolic disease: a research review

Baldwin, JR; Danese, A; (2019) Pathways from childhood maltreatment to cardiometabolic disease: a research review. Adoption and Fostering , 43 (3) pp. 329-339. 10.1177/0308575919856175. Green open access

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Abstract

Childhood maltreatment is a risk factor for poor physical health outcomes in later life, such as cardiovascular disease and type 2 diabetes. In order to target preventive interventions to reduce this risk, it is important to understand the biological mechanisms linking childhood maltreatment to cardiometabolic disorders. Research reviewed here suggests that maltreated children show alterations in biological systems relating to metabolism and the immune system which could, in turn, increase the risk of long-term cardiometabolic disease risk. Specifically, maltreated children show an elevated risk of obesity in adulthood and greater inflammation levels in adolescence and adulthood. These findings from observational studies of humans are consistent with evidence from experimental animal models showing the causal effects of early life stress on obesity and immune function. To help prevent maltreated children from developing cardiometabolic disease later in life, clinical assessment and treatment should focus on physical as well as mental health.

Type: Article
Title: Pathways from childhood maltreatment to cardiometabolic disease: a research review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0308575919856175
Publisher version: https://doi.org/10.1177/0308575919856175
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Childhood maltreatment, childhood victimisation, early life stress, obesity, inflammation, physical health
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10084574
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