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MAVRIC: A Multicentre Randomised Controlled Trial of Transabdominal Versus Transvaginal Cervical Cerclage

Shennan, A; Chandiramani, M; Bennett, P; David, AL; Girling, J; Ridout, A; Seed, PT; ... Carter, J; + view all (2020) MAVRIC: A Multicentre Randomised Controlled Trial of Transabdominal Versus Transvaginal Cervical Cerclage. American Journal of Obstetrics and Gynecology , 222 (3) 261.e1-261.e9. 10.1016/j.ajog.2019.09.040. Green open access

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Abstract

Background: Vaginal cerclage (a suture around the cervix) is commonly placed in women with recurrent pregnancy loss. These women may experience late miscarriage or extreme preterm delivery, despite being managed with cerclage. Transabdominal cerclage has been advocated following failed cerclage, although its efficacy is unproven by randomised controlled trial. / Objective: The objective of this study was to compare transabdominal cerclage or high vaginal cerclage to low vaginal cerclage in women with a history of failed cerclage. Our primary outcome was delivery before 32 completed weeks of pregnancy. / Study Design: This was a multicentre randomised controlled trial. Women were randomly assigned (1:1:1) to receive transabdominal cerclage, high vaginal cerclage or low vaginal cerclage, either prior to conception or before 14 weeks’ gestation. / Results: 111/139 women recruited who conceived were analysed: 39 to transabdominal cerclage, 39 to high vaginal cerclage and 33 to low vaginal cerclage. Rates of preterm birth <32 weeks were significantly lower in women who received transabdominal cerclage compared to low vaginal cerclage [8% (3/39) v 38% (15/39), RR 0.23 (95% CI 0.07 to 0.76), p=0.0078]. Number needed to treat to prevent one preterm birth was 3.9 (95% CI 2.2 to 13.3). There was no difference in preterm birth rates between high and low vaginal cerclage [38% (15/39) vs 33% (11/33), RR 1.15 (95% CI 0.62 to 2.16), p=0.81]. No neonatal deaths occurred. In an exploratory analysis, women with transabdominal cerclage had fewer fetal losses compared to low vaginal cerclage [3% (1/39) vs 21% (7/33), RR 0.12 (95% CI 0.016 to 0.93), p=0.02]. Number needed to treat to prevent one fetal loss was 5.3 (95% CI 2.9 to 26). / Conclusions: Transabdominal cerclage is the treatment of choice for women with failed vaginal cerclage. It is superior to low vaginal cerclage in reducing risk of early preterm birth and fetal loss in women with previous failed vaginal cerclage. High vaginal cerclage does not confer this benefit. Numbers needed to treat are sufficiently low to justify transabdominal surgery and caesarean delivery required in this select cohort.

Type: Article
Title: MAVRIC: A Multicentre Randomised Controlled Trial of Transabdominal Versus Transvaginal Cervical Cerclage
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ajog.2019.09.040
Publisher version: https://doi.org/10.1016/j.ajog.2019.09.040
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Failed stitch, Recurrent late miscarriage, Transabdominal cerclage, Vaginal cerclage
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10084523
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