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Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment

Rawlinson, KA; Lapraz, F; Ballister, ER; Terasaki, M; Rodgers, J; McDowell, RJ; Girstmair, J; ... Telford, MJ; + view all (2019) Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment. eLife , 8 , Article e42149. 10.7554/eLife.45465. Green open access

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Abstract

Animals detect light using opsin photopigments. Xenopsin, a recently classified subtype of opsin, challenges our views on opsin and photoreceptor evolution. Originally thought to belong to the Gαi-coupled ciliary opsins, xenopsins are now understood to have diverged from ciliary opsins in pre-bilaterian times, but little is known about the cells that deploy these proteins, or if they form a photopigment and drive phototransduction. We characterized xenopsin in a flatworm, Maritigrella crozieri, and found it expressed in ciliary cells of eyes in the larva, and in extraocular cells around the brain in the adult. These extraocular cells house hundreds of cilia in an intra-cellular vacuole (phaosome). Functional assays in human cells show Maritigrella xenopsin drives phototransduction primarily by coupling to Gαi. These findings highlight similarities between xenopsin and c-opsin and reveal a novel type of opsin-expressing cell that, like jawed vertebrate rods, encloses the ciliary membrane within their own plasma membrane.

Type: Article
Title: Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.45465
Publisher version: https://doi.org/10.7554/eLife.45465
Language: English
Additional information: © 2019, Rawlinson et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Maritigrella crozieri, ciliary photoreceptor, developmental biology, evolutionary biology, flatworm, phaosome, photopigment, xenopsin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10084494
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