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Genes, pathways and risk prediction in Alzheimer's disease

Hardy, J; Escott-Price, V; (2019) Genes, pathways and risk prediction in Alzheimer's disease. Human Molecular Genetics , 28 (R2) R235-R240. 10.1093/hmg/ddz163. Green open access

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Abstract

The failure of recent clinical trials in Alzheimer's disease has highlighted the need for the development of a more complete understanding of the pathogenesis of the disorder and also a belief that therapies may only work if given very early in the disease process before overt symptoms occur. The rare, early onset forms of the disease are all caused by mutations which make amyloid deposition a more likely event. Here we discuss the recent data showing that, in contrast, much of the risk of late onset disease is encoded by loci involved in lipid metabolism and/or encoded by microglia. We discuss these finding and suggest that amyloid induced membrane damage may be a key factor in disease and also review the evidence that genome wide genetic analysis can substantially help in the prediction of those individuals at high risk of disease in the general population.

Type: Article
Title: Genes, pathways and risk prediction in Alzheimer's disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/hmg/ddz163
Publisher version: https://doi.org/10.1093/hmg/ddz163
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: amyloid, alzheimer's disease, fat metabolism, genes, genetics, genetic analysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10084254
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