Guzmán-Herrera, A;
Mao, Y;
(2020)
Polarity during tissue repair, a multiscale problem.
Current Opinion in Cell Biology
, 62
pp. 31-36.
10.1016/j.ceb.2019.07.015.
(In press).
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Abstract
Tissue repair is essential for all organisms, as it protects the integrity and function of tissues and prevents infections and diseases. It takes place at multiple scales, from macroscopic to microscopic levels. Most mechanisms driving tissue repair rely on the correct polarisation of collective cell behaviours, such as migration and proliferation, and polarisation of cytoskeletal and junctional components. Furthermore, re-establishment and maintenance of cell polarity are fundamental for a tissue to be fully repaired and for withstanding mechanical stress during homeostasis and repair. Recent evidence highlights an important role for the interplay between cell polarity and tissue mechanics that are critical in tissue repair.
| Type: | Article |
|---|---|
| Title: | Polarity during tissue repair, a multiscale problem |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2019.07.015 |
| Publisher version: | https://doi.org/10.1016/j.ceb.2019.07.015 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10084066 |
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