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What goes up must come down: insights from studies on descending controls acting on spinal pain processing

Lockwood, S; Dickenson, AH; (2020) What goes up must come down: insights from studies on descending controls acting on spinal pain processing. Journal of Neural Transmission , 127 pp. 541-549. 10.1007/s00702-019-02077-x. Green open access

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Abstract

Descending controls link higher processing of noxious signals to modulation of spinal cord responses to their noxious inputs. It has become possible to study one key inhibitory system in animals and humans using one painful stimulus to attenuate another distant response and so eliciting diffuse noxious inhibitory controls (DNIC) or the human counterpart, conditioned pain modulation (CPM). Here, we discuss the neuronal pathways in both species, their pharmacology and examine changes in descending controls with a focus on osteoarthritis. We will also discuss the opposing descending facilitatory system. Strong parallels between DNIC and CPM emphasize the possibility of forward and reverse translation.

Type: Article
Title: What goes up must come down: insights from studies on descending controls acting on spinal pain processing
Location: Austria
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00702-019-02077-x
Publisher version: https://doi.org/10.1007/s00702-019-02077-x
Language: English
Additional information: Copyright © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: 5-hydroxytrptamine, Conditioned pain modulation (CPM), Descending controls, Diffuse noxious inhibitory controls (DNIC), Noradrenaline, Spinal cord
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10084013
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