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Hybrid Reaction Systems for the Synthesis of Alkylated Compounds based upon Cu-catalyzed Coupling of Radicals and Organometallic Species

Takeuchi, K; Murata, Y; Hirata, G; Sheppard, TD; Nishikata, T; (2020) Hybrid Reaction Systems for the Synthesis of Alkylated Compounds based upon Cu-catalyzed Coupling of Radicals and Organometallic Species. Chemical Record , 20 (5) pp. 403-412. 10.1002/tcr.201900053. Green open access

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Abstract

A transition metal catalyzed alkylation with an alkyl halide is one of the most difficult reactions to achieve, because of the difficult oxidative addition of an alkyl‐halogen bond to a metal, and the tendency of the resulting alkylmetal intermediate to undergo a β‐hydride elimination reaction to give an olefin. In this review, we discuss hybrid reaction systems involving Cu catalyzed combination of radicals and organometallic species, which enable facile alkylation reactions to construct C−C and C‐heteroatom bonds. This paper highlights recent progress in arylation, alkenylation, alkynylation, cyclization, addition and introduction of heteroatoms via these hybrid reaction systems.

Type: Article
Title: Hybrid Reaction Systems for the Synthesis of Alkylated Compounds based upon Cu-catalyzed Coupling of Radicals and Organometallic Species
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/tcr.201900053
Publisher version: https://doi.org/10.1002/tcr.201900053
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: copper, radical, alkylation, addition, coupling
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10083976
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