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Deconvolving Convolutional Neural Network for Cell Detection

Raza, SEA; AbdulJabbar, K; Jamal-Hanjani, M; Veeriah, S; Le Quesne, J; Swanton, C; Yuan, Y; (2019) Deconvolving Convolutional Neural Network for Cell Detection. In: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). (pp. pp. 891-894). IEEE: Venice, Italy,. Green open access

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Abstract

Automatic cell detection in histology images is a challenging task due to varying size, shape and features of cells and stain variations across a large cohort. Conventional deep learning methods regress the probability of each pixel belonging to the centre of a cell followed by detection of local maxima. We present deconvolution as an alternate approach to local maxima detection. The ground truth points are convolved with a mapping filter to generate artifical labels. A convolutional neural network (CNN) is modified to convolve it’s output with the same mapping filter and is trained for the mapped labels. Output of the trained CNN is then deconvolved to generate points as cell detection. We compare our method with state-of-the-art deep learning approaches where the results show that the proposed approach detects cells with comparatively high precision and F1-score.

Type: Proceedings paper
Title: Deconvolving Convolutional Neural Network for Cell Detection
Event: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)
Location: Venice, ITALY
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISBI.2019.8759333
Publisher version: https://doi.org/10.1109/ISBI.2019.8759333
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cell detection, convolutional neural network, Micro-Net, deconvolution, local maxima detection.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10083708
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