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A hybrid discrete–continuum approach for modelling microcirculatory blood flow

Shipley, RJ; Smith, AF; Sweeney, PW; Pries, AR; Secomb, TW; (2020) A hybrid discrete–continuum approach for modelling microcirculatory blood flow. Mathematical Medicine and Biology , 37 (1) pp. 40-57. 10.1093/imammb/dqz006. Green open access

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Abstract

In recent years, biological imaging techniques have advanced significantly and it is now possible to digitally reconstruct microvascular network structures in detail, identifying the smallest capillaries at sub-micron resolution and generating large 3D structural data sets of size >106 vessel segments. However, this relies on ex vivo imaging; corresponding in vivo measures of microvascular structure and flow are limited to larger branching vessels and are not achievable in three dimensions for the smallest vessels. This suggests the use of computational modelling to combine in vivo measures of branching vessel architecture and flows with ex vivo data on complete microvascular structures to predict effective flow and pressures distributions. In this paper, a hybrid discrete–continuum model to predict microcirculatory blood flow based on structural information is developed and compared with existing models for flow and pressure in individual vessels. A continuum-based Darcy model for transport in the capillary bed is coupled via point sources of flux to flows in individual arteriolar vessels, which are described explicitly using Poiseuille’s law. The venular drainage is represented as a spatially uniform flow sink. The resulting discrete–continuum framework is parameterized using structural data from the capillary network and compared with a fully discrete flow and pressure solution in three networks derived from observations of the rat mesentery. The discrete–continuum approach is feasible and effective, providing a promising tool for extracting functional transport properties in situations where vascular branching structures are well defined.

Type: Article
Title: A hybrid discrete–continuum approach for modelling microcirculatory blood flow
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/imammb/dqz006
Publisher version: https://doi.org/10.1093/imammb/dqz006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Microcirculation, Darcy flow, homogenization, capillary networks, blood flow
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10083630
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