Stagg, HR;
Abubakar, I;
Campbell, CNJ;
Copas, A;
Darvell, M;
HORNE, R;
Kielmann, K;
... Lipman, M; + view all
(2019)
The IMPACT Study: Intervening with a Manualised Package to AChieve treatment adherence in people with Tuberculosis. A protocol paper for a mixed methods study, including a pilot randomised controlled trial.
BMJ Open
, 9
, Article e032760. 10.1136/bmjopen-2019-032760.
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Abstract
Introduction: Compared with the rest of the UK and Western Europe, England has high rates of the infectious disease tuberculosis (TB). TB is curable, although treatment is for at least 6 months and longer when disease is drug resistant. If patients miss too many doses (non-adherence), they may transmit infection for longer and the infecting bacteria may develop resistance to the standard drugs used for treatment. Non-adherence may therefore risk both their health and that of others. Within England, certain population groups are thought to be at higher risk of non-adherence, but the factors contributing to this have been insufficiently determined, as have the best interventions to promote adherence. The objective of this study was to develop a manualised package of interventions for use as part of routine care within National Health Services to address the social and cultural factors that lead to poor adherence to treatment for TB disease. Methods and analysis: This study uses a mixed-methods approach, with six study components. These are (1) scoping reviews of the literature; (2) qualitative research with patients, carers and healthcare professionals; (3) development of the intervention; (4) a pilot randomised controlled trial of the manualised intervention; (5) a process evaluation to examine clinical utility; and (6) a cost analysis.
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