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Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret

Bimbard, C; Demene, C; Girard, C; Radtke-Schuller, S; Shamma, S; Tanter, M; Boubenec, Y; (2018) Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret. eLife , 7 , Article e35028. 10.7554/eLife.35028. Green open access

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Abstract

A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve the functional organization of sensory systems at multiple scales in awake animals, both within small structures by precisely mapping and differentiating sensory responses, and between structures by elucidating the connectivity scheme of top-down projections. We demonstrate that fUS provides stable (over days), yet rapid, highly-resolved 3D tonotopic maps in the auditory pathway of awake ferrets, thus revealing its unprecedented functional resolution (100/300µm). This was performed in four different brain regions, including very small (1–2 mm3 size), deeply situated subcortical (8 mm deep) and previously undescribed structures in the ferret. Furthermore, we used fUS to map long-distance projections from frontal cortex, a key source of sensory response modulation, to auditory cortex.

Type: Article
Title: Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.35028
Publisher version: https://doi.org/10.7554/eLife.35028
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, INTRINSIC OPTICAL SIGNALS, ELECTRICAL MICROSTIMULATION, CEREBRAL-CORTEX, IN-VIVO, BRAIN, DOPPLER, ORGANIZATION, RESPONSES, STIMULI, NEURONS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10083574
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