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Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

Ostrander, EA; Wang, GD; Larson, G; Vonholdt, BM; Davis, BW; Jagannathan, V; Hitte, C; ... Dog10K Consortium; + view all (2019) Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. National Science Review , 6 (4) pp. 810-824. 10.1093/nsr/nwz049. Green open access

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Abstract

Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

Type: Article
Title: Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nsr/nwz049
Publisher version: https://doi.org/10.1093/nsr/nwz049
Language: English
Additional information: © The Author(s) 2019. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: genomics, genome-wide association studies (GWAS), breed, selection, variation, evolution
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10083479
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