Vicente-Munuera, P;
Gómez-Gálvez, P;
Tetley, RJ;
Forja, C;
Tagua, A;
Letrán, M;
Tozluoglu, M;
... Escudero, LM; + view all
(2020)
EpiGraph: an open-source platform to quantify epithelial organization.
Bioinformatics
, 36
(4)
pp. 1314-1316.
10.1093/bioinformatics/btz683.
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Abstract
SUMMARY: Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond the traditional polygon distribution analysis, capturing other organizational traits that improve the characterization of epithelia. EpiGraph can objectively compare the rearrangements of epithelial cells during development and homeostasis to quantify how the global ensemble is affected. Importantly, it has been implemented in the open-access platform Fiji. This makes EpiGraph very user friendly, with no programming skills required.
| Type: | Article |
|---|---|
| Title: | EpiGraph: an open-source platform to quantify epithelial organization |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/bioinformatics/btz683 |
| Publisher version: | https://doi.org/10.1093/bioinformatics/btz683 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10083201 |
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