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Functional brain alterations following mild-to-moderate sensorineural hearing loss in children

Calcus, A; Tuomainen, O; Campos, A; Rosen, S; Halliday, LF; (2019) Functional brain alterations following mild-to-moderate sensorineural hearing loss in children. eLife 10.7554/eLife.46965. (In press). Green open access

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Abstract

Auditory deprivation in the form of deafness during development leads to lasting changes in central auditory system function. However, less is known about the effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. Here, we used a longitudinal design to examine late auditory evoked responses and mismatch responses to nonspeech and speech sounds for children with MMHL. At Time 1, younger children with MMHL (8-12 years; n = 23) showed age-appropriate mismatch negativities (MMNs) to sounds, but older children (12-16 years; n = 23) did not. Six years later, we re-tested a subset of the younger (now older) children with MMHL (n = 13). Children who had shown significant MMNs at Time 1 showed MMNs that were reduced and, for nonspeech, absent at Time 2. Our findings demonstrate that even a mild-to-moderate hearing loss during early-to-mid childhood can lead to changes in the neural processing of sounds in late childhood/adolescence.

Type: Article
Title: Functional brain alterations following mild-to-moderate sensorineural hearing loss in children
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.46965
Publisher version: https://doi.org/10.7554/eLife.46965
Language: English
Additional information: Copyright © 2019, Calcus et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) permitting unrestricted use and redistribution provided that the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Speech, Hearing and Phonetic Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10083042
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