Mesraoua, B;
Deleu, D;
Kullmann, DM;
Shetty, AK;
Boon, P;
Perucca, E;
Mikati, MA;
(2019)
Novel therapies for epilepsy in the pipeline.
Epilepsy & Behavior
, 97
pp. 282-290.
10.1016/j.yebeh.2019.04.042.
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Abstract
Despite the availability of many antiepileptic drugs (AEDs) (old and newly developed) and, as recently suggested, their optimization in the treatment of patients with uncontrolled seizures, more than 30% of patients with epilepsy continue to experience seizures and have drug-resistant epilepsy; the management of these patients represents a real challenge for epileptologists and researchers. Resective surgery with the best rates of seizure control is not an option for all of them; therefore, research and discovery of new methods of treating resistant epilepsy are of extreme importance. In this article, we will discuss some innovative approaches, such as P-glycoprotein (P-gp) inhibitors, gene therapy, stem cell therapy, traditional and novel antiepileptic devices, precision medicine, as well as therapeutic advances in epileptic encephalopathy in children; these treatment modalities open up new horizons for the treatment of patients with drug-resistant epilepsy.
| Type: | Article |
|---|---|
| Title: | Novel therapies for epilepsy in the pipeline |
| Location: | Hamad Medical City, QATAR |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.yebeh.2019.04.042 |
| Publisher version: | https://doi.org/10.1016/j.yebeh.2019.04.042 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Clinical Neurology, Psychiatry, Neurosciences & Neurology, Epilepsy, Seizure, Drug resistance, Treatment, TEMPORAL-LOBE EPILEPSY, TRANSCRANIAL MAGNETIC STIMULATION, DRUG-RESISTANT EPILEPSY, TRANSPORTER P-GLYCOPROTEIN, REDUCES SEIZURE FREQUENCY, ANTIEPILEPTIC DRUGS, LONG-TERM, PRECISION MEDICINE, QUINIDINE THERAPY, NERVE-STIMULATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10082978 |
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