Sarnak, MJ;
Amann, K;
Bangalore, S;
Cavalcante, JL;
Charytan, DM;
Craig, JC;
Gill, JS;
... Zarbock, A; + view all
(2019)
Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review.
Journal of the American College of Cardiology
, 74
(14)
pp. 1823-1838.
10.1016/j.jacc.2019.08.1017.
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Abstract
Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, including inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism. CKD and end-stage kidney disease not only increase the risk of CAD, but they also modify its clinical presentation and cardinal symptoms. Management of CAD is complicated in CKD patients, due to their likelihood of comorbid conditions and potential for side effects during interventions. This summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference on CAD and CKD (including end-stage kidney disease and transplant recipients) seeks to improve understanding of the epidemiology, pathophysiology, diagnosis, and treatment of CAD in CKD and to identify knowledge gaps, areas of controversy, and priorities for research.
| Type: | Article |
|---|---|
| Title: | Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jacc.2019.08.1017 |
| Publisher version: | https://doi.org/10.1016/j.jacc.2019.08.1017 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Acute coronary syndromes, calcification, chronic kidney disease, coronary artery disease, revascularization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10082838 |
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