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Closed-loop all-optical interrogation of neural circuits in vivo

Zhang, Z; Russell, LE; Packer, AM; Gauld, OM; Hausser, M; (2018) Closed-loop all-optical interrogation of neural circuits in vivo. Nature Methods , 15 (12) pp. 1037-1040. 10.1038/s41592-018-0183-z. Green open access

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Abstract

Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.

Type: Article
Title: Closed-loop all-optical interrogation of neural circuits in vivo
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41592-018-0183-z
Publisher version: https://doi.org/10.1038/s41592-018-0183-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10082760
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